FITC标记的人乙肝病毒pre S1/S2蛋白抗体
产品名称： FITC标记的人乙肝病毒pre S1/S2蛋白抗体
英文名称： Anti-Hepatitis B Virus Surface Antigen/FITC
产品编号： HZ-2327R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-Hepatitis B Virus Surface Antigen/FITC Conjugated antibody
FITC标记的人乙肝病毒pre S1/S2蛋白抗体
| 英文名称 | Anti-Hepatitis B Virus Surface Antigen/FITC |
| 中文名称 | FITC标记的人乙肝病毒pre S1/S2蛋白抗体 |
| 别 名 | Hepatitis B Virus Surface Antigen; Hepatitis B virus S1/S2 protein; Hepatitis B virus PreS1; Hepatitis B virus pre S1 protein; HBV pre S1 protein; HBSAG_HBVD2; HBSAG_HBVC5; Hepatitis B Virus Major surface antigen; Large envelope protein; Large surface protein; L glycoprotein; Major surface antigen; Large S protein; L-HBsAg; LHB. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细菌及病毒 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Hepatitis B virus(HBVD2, HBVC5) |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 31/44kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from HBSAG_HBVD2 pre S1/S2 protein |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Hepatitis B Virus (HBV) infection induces a disease state characterised by liver damage, inflammation and viral persistence. Infection also increases the risk of hepatocellular carcinoma. HBV belongs to the Hepadnaviridae family of viruses. Its genome consists of partially double stranded circular DNA. The DNA is enclosed in a nucleocapsid, or core antigen (HBcAg), which is surrounded by a spherical envelope (surface antigen or HBsAg). The core antigen shares its sequences with the e antigen (HBeAg) but no cross reactivity between the two proteins has been observed. The HBV genome also encodes a DNA polymerase that also acts as a reverse transcriptase. Hepatitis B infection is normally diagnosed from serological tests that detect HBsAg but as the disease progresses this antigen may no longer be present in the blood and tests for HBcAg are used. If HBsAg can be detected in the blood for longer than six months, chronic hepatitis B is diagnosed. The antigenic determinant of the protein moiety of the HBsAg determines specific characteristics of different serotypes and provides the basis of immunodetection. HBsAg has antigenic heterogeneity, specifically, two pairs of sub specific determinants, d/y and w/r allow the following combinations: adw, ayw, adr, ayr. Function: Li-HBsAg interacts with capsid protein and with HDV Large delta antigen. Isoform M associates with host chaperone CANX through its pre-S2 N glycan. This association may be essential for M proper secretion. Subunit: Li-HBsAg interacts with capsid protein and with HDV Large delta antigen. Isoform M associates with host chaperone CANX through its pre-S2 N glycan. This association may be essential for M proper secretion. Subcellular Location: Virion membrane. Post-translational modifications: Isoform M is N-terminaly acetylated at a ratio of 90%, and N-glycosylated at the pre-S2 region. Myristoylated. Similarity: Belongs to the orthohepadnavirus major surface antigen family. Database links: Entrez Gene: 2703546 Hepatitis B virus SwissProt: P03142 Hepatitis B virus Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 乙型肝肝炎病毒颗粒直径42nm，由包膜与核衣壳组成，包膜含有碳水化合物、蛋白质和脂类。其中蛋白质为主要抗原成分，包括S抗原：pre-s1区和pre-s2区，这些抗原成分在病毒侵入细胞过程中有着至关重要的作用，为深入研究乙型肝肝炎病毒发病机理及变异有着至关重要的作用 |
乙型肝炎病毒（HBV）感染是一种以肝损伤、炎症和病毒持续性为特征的疾病状态。感染也会增加肝细胞癌的风险。HBV属于Hepadnaviridae氏病毒家族。其基因组由部分双链环状DNA组成。DNA被包裹在核衣壳或核心抗原（HBcAg）中，其被球形包膜（表面抗原或HBsAg）包围。核心抗原与E抗原（HBeAg）共享其序列，但未观察到两种蛋白之间的交叉反应性。HBV基因组也编码一种DNA聚合酶，它也起反转录酶的作用。乙型肝炎病毒感染通常是通过检测HBsAg的血清学试验来诊断的，但随着病情的发展，这种抗原可能不再存在于血液中，而使用HBcAg试验。如果HBsAg能够在血液中检测超过六个月，则诊断为慢性乙型肝炎。HBsAg蛋白部分的抗原决定簇决定了不同血清型的特异性，为免疫检测提供了依据。HBsAg具有抗原异质性，特别是两对亚特异性决定物，D/Y和W/R允许以下组合：ADW、AYW、ADR、埃尔。