Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 Lys-4 (H3K4me) and dimethylates histone H3 Lys-36 (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates Lys-370 of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates Lys-860 of RB1/RB.Shipped at 4°C. Store at -20oC. *   http://www.creative-diagnostics.com/Anti-SMYD2-PAb-198666-147.htm