MYST1 (C-term) Peptide
产品名称： MYST1 (C-term) Peptide
英文名称： MYST1 (C-term) Peptide
产品编号： P0235
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MYST1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to amino acids 417-446 at C-terminus of human MYST1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma.
Pfister S, Rea S, Taipale M, Mendrzyk F, Straub B, Ittrich C, Thuerigen O, Sinn HP, Akhtar A, Lichter P.Int J Cancer. 2008 Mar 15;122(6):1207-13.
- 2.
- The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis.
Gupta A, Guerin-Peyrou TG, Sharma GG, Park C, Agarwal M, Ganju RK, Pandita S, Choi K, Sukumar S, Pandita RK, Ludwig T, Pandita TK.Mol Cell Biol. 2008 Jan;28(1):397-409. Epub 2007 Oct 29.
- 3.
- Males absent on the first (MOF): from flies to humans.
Rea S, Xouri G, Akhtar A.Oncogene. 2007 Aug 13;26(37):5385-94.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of MYST1 polyclonal antibody (Cat # PAB2349) in K-562 cell line lysates (35 ug/lane). MYST1 (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with MYST1 polyclonal antibody (Cat # PAB2349) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
- Entrez GeneID:
- 84148
- Protein Accession#:
- NP_115564;Q9H7Z6
- Gene Name:
- MYST1
- Gene Alias:
- FLJ14040,KAT8,MOF,hMOF
- Gene Description:
- MYST histone acetyltransferase 1
- Omim ID:
- 609912
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The MYST family of histone acetyltransferases, which includes MYST1, is named for the founding members MOZ (MYST3; MIM 601408), yeast YBF2 and SAS2, and TIP60 (HTATIP; MIM 601409). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin (Neal et al., 2000 [PubMed 10786633]).[supplied by OMIM
- Other Designations:
- histone acetyltransferase MYST1,ortholog of Drosophila males absent on the first (MOF)
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