CHN2 polyclonal antibody
产品名称： CHN2 polyclonal antibody
英文名称： CHN2 polyclonal antibody
产品编号： PAB15616
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised aganist synthetic peptide of CHN2.
- Immunogen:
- A synthetic peptide corresponding to C-terminus of human CHN2.
- Sequence:
- C-QILIENEDVLF
- Host:
- Goat
- Theoretical MW (kDa):
- 38.2, 53.9
- Reactivity:
- Human
- Specificity:
- This antibody is expected to recognize both reported isoforms (NP_004058.1; NP_001035025.1).
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:8000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-6 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells.
Siliceo M, Merida I.J Biol Chem. 2009 Apr 24;284(17):11354-63. Epub 2009 Feb 6.
- Application Image
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- ELISA
- Entrez GeneID:
- 1124
- Protein Accession#:
- NP_001035025.1
- Gene Name:
- CHN2
- Gene Alias:
- ARHGAP3,BCH,MGC138360,RHOGAP3
- Gene Description:
- chimerin (chimaerin) 2
- Omim ID:
- 602857
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
- Other Designations:
- beta chimerin,rho-GTPase-activating protein 3